Dosing and Drug
CABENUVA must be administered by a healthcare professional. Before initiation of clinician-administered CABENUVA, ensure patients agree to the required monthly dosing schedule and counsel patients about the importance of adherence to scheduled dosing visits.1 Patients who miss a scheduled injection visit should be clinically reassessed to ensure resumption of therapy remains appropriate.
Recommended Dosing Schedule
Oral lead-in: month 1 (at least 28 days)
To assess tolerability of CABENUVA, patients switching to CABENUVA will take an oral lead-in, 2 pills once daily with a meal, for one month (at least 28 days).1
Initiation injections: (one-time dosing)
On the last day of oral lead-in, patients will receive their initiation injections. The initiation injections are administered as 2 IM injections at separate gluteal sites (opposite sides or 2 cm apart) during same visit.1
Continuation injections: (once-monthly)
Starting in Month 3, patients will begin continuation injections of CABENUVA. Continuation injections are administered as 2 IM injections at separate gluteal sites (opposite sides or 2 cm apart) during same visit.1 CABENUVA has dosing flexibility, allowing for continuation injections to be given up to 7 days before or 7 days after the Target Treatment Date.1
Drug-drug interaction recommendations do not vary based on dosing schedule.
- Recommendations are based on drug-drug interactions observed after oral administration of cabotegravir and rilpivirine or predicted interactions due to the expected magnitude of the interaction and potential loss of virologic response1
Concomitant drug class
Effect on concentration1
|Coadministration with CABENUVA is contraindicated due to potential for loss of virologic response and development of resistance.|
(more than a single-dose treatment)
St John’s wort (Hypericum perforatum)
Macrolide or ketolide antibiotics:
|Macrolides are associated with risk of Torsade de Pointes. Where possible, consider alternatives such as azithromycin, which increases rilpivirine concentrations less.|
|No dose adjustment required when starting coadministration with CABENUVA. Clinical monitoring is recommended as methadone maintenance therapy may need to be adjusted in some patients.|
↑ = Increase, ↓ = Decrease, ↔︎ = No Change
Dosing recommendations when switching from every-2-month to once-monthly CABENUVA
- Administer 2-mL of cabotegravir and rilpivirine 2 months after the last 3-mL doses of each medicine, and continue once monthly thereafter
Scheduling monthly injections
Adherence to the monthly injection dosing schedule is strongly recommended. Before initiating CABENUVA, counsel your patients about the importance of continued medication adherence and scheduled visits to help maintain viral supression.1
Setting a consistent monthly injection date, the Target Treatment Date, can help keep your patients on track. It is recommended that patients receive their monthly injection on the same date each month, making the Target Treatment Date fall between the 1st and 28th of each month.
CABENUVA has dosing flexibility, allowing for continuation injections to be given up to 7 days before or 7 days after the Target Treatment Date.1
Adherence to the monthly injection dosing schedule is strongly recommended. Patients who miss a scheduled injection visit should be clinically reassessed to ensure resumption of therapy remains appropriate.1
Planned Missed Injections
If a patient plans to miss a scheduled injection visit by more than 7 days, oral therapy (one 30-mg cabotegravir tablet and one 25-mg rilpivirine tablet once-daily with a meal) can be taken to replace up to 2 consecutive monthly injection visits. The first dose of oral therapy should be taken approximately 1 month after the last injection dose of CABENUVA and continued until the day injection dosing is restarted.
Unplanned Missed Injections
If monthly injections are missed or delayed by more than 7 days and oral therapy has not been taken in the interim, clinically reassess the patient to determine if resumption of injection dosing remains appropriate.
CONTINUING AFTER MISSED INJECTIONS
Dosing and administration guide
Alternative Site for Administration (ASA)
For practices that are not yet equipped to administer CABENUVA injections or prefer to have injections administered to patients off-site, an ASA may be an appropriate option.
What is an ASA?
An ASA is a flexible option for patients to receive CABENUVA injections outside of the prescribing physician’s office setting. Additionally, ViiVConnect may help you locate an ASA. Please indicate your ASA request on the CABENUVA Enrollment Form.
How to ﬁnd an ASA for your patient
Find an ASA nearby with the CABENUVA ASA Locator Tool located on the ViiVConnect website. Enter the ZIP code or use your location to search for injection facilities within a selected search radius. Inclusion of facilities in this ASA Locator does not imply a referral, recommendation, or endorsement by ViiV Healthcare.
Is your facility interested in becoming an ASA?
If you would like to list your facility on the CABENUVA ASA Locator Tool, download and complete the agreement form on the ASA Locator page.
- CABENUVA [package insert]. Research Triangle Park, NC: ViiV Healthcare; 2021.