For virologically suppressed adults with HIV-1. See Full Indication.

Dosing and Drug
Interactions of
Every-2-Month CABENUVA

Every-2-month CABENUVA is administered as 2 intramuscular injections by a healthcare professional every 2 months. Adherence to the dosing schedule is strongly recommended.

Recommended Every-2-Month Dosing Schedule

Starting patients on every-2-month CABENUVA

 

Before initiation of CABENUVA, ensure patients agree to the required every-2-month dosing schedule, and counsel patients about the importance of adherence to scheduled dosing visits. Patients who miss a scheduled injection visit should be clinically reassessed to ensure resumption of therapy remains appropriate.1

RECOMMENDED EVERY-2-MONTH DOSING SCHEDULE1

Recommended Dosing Schedule
Recommended Every 2 Month Chart
  • Adherence to the every-2-month dosing schedule is strongly recommended. Setting a consistent injection date, the Target Treatment Date, can help keep your patients on track1
  • CABENUVA has dosing flexibility, allowing for injections to be given up to 7 days before or after the Target Treatment Date1

IM=intramuscular; LA=long-acting.

Drug-drug interaction recommendations do not vary based on dosing schedule.

Drug-drug Interactions

  • Recommendations are based on drug-drug interactions observed after oral administration of cabotegravir and rilpivirine or predicted interactions due to the expected magnitude of the interaction and potential loss of virologic response1

Concomitant drug class
Drug name1

Effect on concentration1

Recommendation1

Anticonvulsants:

Carbamazepine

Oxcarbazepine

Phenobarbital

Phenytoin

Cabotegravir
Rilpivirine
Coadministration with CABENUVA is contraindicated due to potential for loss of virologic response and development of resistance.

Antimycobacterials:

Rifampin

Rifapentine

Rifabutin

Cabotegravir
Rilpivirine

Glucocorticoid (systemic):

Dexamethasone

(more than a single-dose treatment)

Rilpivirine

Herbal product:

St John’s wort (Hypericum perforatum)

Rilpivirine

Macrolide or ketolide antibiotics:

Azithromycin

Clarithromycin

Erythromycin

↔︎Cabotegravir
Rilpivirine
Macrolides are associated with risk of Torsade de Pointes. Where possible, consider alternatives such as azithromycin, which increases rilpivirine concentrations less.

Narcotic analgesic:

Methadone


↔︎ Cabotegravir
↔︎ Rilpivirine
No dose adjustment required when starting coadministration with CABENUVA. Clinical monitoring is recommended as methadone maintenance therapy may need to be adjusted in some patients.

↑ = Increase, ↓ = Decrease, ↔︎ = No Change

Switching from once-monthly to every-2-month dosing

RECOMMENDATIONS WHEN SWITCHING FROM ONCE-MONTHLY TO EVERY-2-MONTH DOSING OF CABENUVA1

SWITCHING CHART
switching chart

Continuing every-2-month CABENUVA after missed injections

Adherence to the dosing schedule is strongly recommended. Patients who miss a scheduled injections visit should be clinically reassessed to ensure resumption of therapy remains appropriate.1

Planned Missed Injections

If a patient plans to miss scheduled injections visit by more than 7 days, daily oral therapy with cabotegravir and rilpivirine can be prescribed for a duration of up to 2 months to replace 1 missed scheduled every-2-month injections visit1

RESTARTING AFTER PLANNED MISSED INJECTIONS

 

Unplanned Missed Injections

If injections are missed or delayed by more than 7 days and oral therapy has not been taken in the interim, clinically reassess the patient to determine if resumption of injection dosing remains appropriate.

RESTARTING AFTER UNPLANNED MISSED INJECTIONS

unplanned missed injections

Dosing and administration guide

Download this guide to receive information on:

  • CABENUVA dosing kits and storage
  • The CABENUVA dosing schedule
  • Administering the initiation and continuation injections
  • Managing missed injections
  • Injection considerations to share with your patients

Alternative Site for Administration (ASA)

For practices that are not yet equipped to administer CABENUVA injections or prefer to have injections administered to patients off-site, an ASA may be an appropriate option.

What is an ASA?

An ASA is a flexible option for patients to receive CABENUVA injections outside of the prescribing physician’s office. Additionally, ViiVConnect may help you locate an ASA. Please indicate your ASA request on the CABENUVA Enrollment Form.

How to find an ASA for your patient

Find an ASA nearby with the CABENUVA ASA Locator Tool located on the ViiVConnect website. Enter the ZIP code or use your location to search for injection facilities within a selected search radius. Inclusion of facilities in this ASA Locator does not imply a referral, recommendation, or endorsement by ViiV Healthcare.

Is your facility interested in becoming an ASA?

If you would like to list your facility on the CABENUVA ASA Locator Tool, download and complete the agreement form on the ASA Locator page.

Reference:

  1. CABENUVA [package insert]. Research Triangle Park, NC: ViiV Healthcare; 2021.

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