VISUAL
CABENUVA logo elements appear separated with the two active ingredients' names.
ViiV Healthcare Logo is displayed.
VOICE-OVER
This is an instructional video for the
TEXT ON SCREEN
cabotegravir
rilpivirine
VISUAL
CABENUVA logo elements join to recreate the CABENUVA logo.
The CABENUVA trade name appears.
ViiV Healthcare Logo is displayed.
VOICE-OVER
administration of CABENUVA.
TEXT ON SCREEN
CABENUVA
cabotegravir 200 mg/mL; rilpivirine 300 mg/mL
extended-release injectable suspensions
VISUAL
Video introduction is displayed.
The CABENUVA Logo is displayed.
VOICE-OVER
Please read the full Instructions for Use (IFU) contained in the 2 CABENUVA Dosing Kits and available at CABENUVAhcp.com
CABENUVA is for Healthcare Professional administration only.
TEXT ON SCREEN
Please read the full Instructions for Use (IFU) contained in the 2 CABENUVA Dosing Kits and available at CABENUVAhcp.com
CABENUVA is for Healthcare Professional administration only.
VISUAL
This scene will outline the purpose of the video, its objectives, and the chapters.
VOICE-OVER
Two topics will be reviewed in this video: Chapter 1 explains the preparation steps for every-2-month and once-monthly CABENUVA, with Chapter 2 focusing on the steps for injection.
TEXT ON SCREEN
Administration Video
Chapter 1 – Preparation
Chapter 2 – Injection
VISUAL
Lightbulb icon explanation.
The CABENUVA Logo is displayed.
VOICE-OVER
The information in this video is based on the CABENUVA Instructions for Use leaflet.
However, where supplementary information is provided, which is not contained in the Instructions for Use leaflet, a lightbulb icon will appear to signify that this is the case.
TEXT ON SCREEN
The information in this video is based on the CABENUVA Instructions for Use leaflet.
However, where supplementary information is provided, which is not contained in the Instructions for Use leaflet, a lightbulb will appear to signify that this is the case.
VISUAL
Dimensions of the outer boxes are shown to support HCPs considering the storage space they may require.
VOICE-OVER
CABENUVA is available in 2 separate dosing kits: the 600-mg/900-mg (per 3-mL) kit, and the 400-mg/600-mg (per 2-mL) kit. In this video, the 600-mg/900-mg kit will be used for demonstration. The preparation and administration instructions are the same for both dosing kits.
TEXT ON SCREEN
600-mg/900-mg Dosing Kit
400-mg/600-mg Dosing Kit
The preparation steps for both the 600-mg/900-mg and 400-mg/600-mg Dosing Kits are the same.
VISUAL
Vial information is shown.
Vials will be rotating.
VOICE-OVER
Each Dosing Kit contains one single-dose vial each of cabotegravir and rilpivirine extended-release suspensions for injection.
A complete dose requires two injections: one each of cabotegravir and rilpivirine.
They do not need further dilution or reconstitution.
Cabotegravir and rilpivirine are for gluteal intramuscular use only and must be administered to separate gluteal intramuscular sites on opposite sides or at least 2 cm apart during the same visit.
The order of administration is not important.
This video will focus on the 600-mg/900-mg Dosing Kit.
TEXT ON SCREEN
600-mg/900-mg Dosing Kit
single-dose vials
cabotegravir 600 mg/3 mL
rilpivirine 900 mg/3 mL
400-mg/600-mg Dosing Kit
single-dose vials
cabotegravir 400 mg/2 mL
rilpivirine 600 mg/2 mL
VISUAL
Storage information is shown.
VOICE-OVER
CABENUVA should be stored in its original packaging in the refrigerator between 36 and 46 degrees Fahrenheit. Do not freeze.
TEXT ON SCREEN
Store in refrigerator at 36°F to 46°F (2°C to 8°C) in the original packaging until ready to use.
Do not freeze.
VISUAL
The Chapter 1 – Preparation cover appears
TEXT ON SCREEN
Chapter 1 – Preparation
VISUAL
A fridge containing the Dosing Kits is displayed. The camera zooms in, a hand opens the fridge, then takes one of the 600-mg/900-mg Dosing Kits to start the preparation.
VOICE-OVER
The preparation steps for both medicines are the same.
First, ensure you select the appropriate dosing kit prior to preparation. Take this dosing kit out of the refrigerator at least 15 minutes prior to giving the injections to allow the suspensions to come to room temperature. It is best to inject the medicine as soon as it reaches room temperature.
TEXT ON SCREEN
Remove Dosing Kit from refrigerator
VISUAL
The hand puts the Dosing Kit on the table. The visual text appears. Then the hand opens the Dosing Kit.
VOICE-OVER
Before giving the injections, the vials may sit in the packaging at room temperature (maximum temperature of 77 degrees Fahrenheit) for up to 6 hours.
TEXT ON SCREEN
The vials may sit in the packaging at room temperature, maximum 77°F (25°C), for up to 6 hours.
VISUAL
The second part of visual text appears on the same scene.
VOICE-OVER
If not used within 6 hours, the medication must be discarded.
Once the vials are removed from the refrigerator, they must be used or discarded. They cannot be cycled in and out of the refrigerator.
TEXT ON SCREEN
If not used within 6 hours, the medication must be discarded.
Once the vials are removed from the refrigerator, they must be used or discarded.
VISUAL
The Dosing Kit contents are collected on a table covered by a medical paper sheet.
Each component will be highlighted one at a time, with information call-outs.
VOICE-OVER
When opening the Dosing Kit of CABENUVA, you will find:
- An Instructions for Use leaflet
- One single-dose vial containing 600 milligrams of cabotegravir
This vial has a brown tint to the glass with an orange cap
- One single-dose vial containing 900 milligrams of rilpivirine
This vial is clear with a yellow cap
- Two 23-gauge, 1½-inch injection needles
- Two syringes
- Two syringe labels
- Two vial adapters
TEXT ON SCREEN
Instructions for Use leaflet
cabotegravir vial
rilpivirine vial
2 injection needles (23G, 1½-inch)
2 syringes
2 syringe labels
2 vial adapters
The cabotegravir vial has a brown tint to the glass.
VISUAL
Text appears showing needle length information.
VOICE-OVER
While the Dosing Kit contains a 23-gauge, 1½-inch needle, you should consider the patient’s build and use medical judgment to select an appropriate needle length.
TEXT ON SCREEN
Consider the patient’s build and use medical judgment to select an appropriate injection needle length.
See Prescribing Information for further details.
VISUAL
Text disappears from frame.
VOICE-OVER
Longer needle lengths may be required for individuals with higher BMI to ensure that the
injection is administered intramuscularly as opposed to subcutaneously.
VISUAL
The camera moves on the right revealing the other components needed (not included) collected on the same table. Call-outs and a pop-up with information appear.
VOICE-OVER
You will also require additional supplies, not included in the packaging:
- Non-sterile gloves
- 4 alcohol wipes
- 4 gauze pads
Adhesive bandages may be used if bleeding occurs.
TEXT ON SCREEN
Non-sterile gloves (not included)
4 alcohol wipes (not included)
4 gauze pads (not included)
Adhesive bandages may be used if bleeding occurs.
VISUAL
The callout moves to reveal the sharps disposal container.
VOICE-OVER
And a suitable sharps container.
TEXT ON SCREEN
Non-sterile gloves (not included)
4 alcohol wipes (not included)
4 gauze pads (not included)
Sharps container (not included)
VISUAL
The hand enters the scene with the vial upside down. A balloon with the zoomed vial pops up showing the expiration date. Then it disappears.
VOICE-OVER
Before proceeding, inspect both vials. If the expiration date has passed,
TEXT ON SCREEN
Check the expiration date and medicine.
Do not use if the expiration date has passed or you can see foreign matter in the vial.
VISUAL
The hand turns the vial to better see the medicine inside the vial. A balloon with the zoomed vial pops up showing the medicine.
VOICE-OVER
or if you can see foreign matter in the vial, do not use.
TEXT ON SCREEN
Check the expiration date and medicine.
Do not use if the expiration date has passed or you can see foreign matter in the vial.
VISUAL
Once the expiration date and medicine are checked, the hand puts the vial back onto the table to let it come to room temperature.
VOICE-OVER
Wait at least 15 minutes to allow the medicines to come to room temperature.
TEXT ON SCREEN
Wait at least 15 minutes to allow the medicines to come to room temperature.
VISUAL
A pop-up appears to advise taking out of fridge when patient checks in to your clinic.
VOICE-OVER
It is best to let the vials come to room temperature naturally.
You may consider using the warmth of your hands to warm the vials more quickly, but make sure the vials do not get above 77 degrees Fahrenheit.
Do not use any other heating methods.
TEXT ON SCREEN
Consider taking out of fridge when patient checks in to your clinic to allow the vials to come to room temperature.
VISUAL
The hand takes the vial.
VOICE-OVER
Once the vial is at room temperature,
VISUAL
The hand shakes the vial vigorously for a full 10 seconds.
VOICE-OVER
hold it firmly and vigorously shake for a full 10 seconds as demonstrated to resuspend the contents.
TEXT ON SCREEN
10 seconds
helpful hint: Shake from the elbow
VISUAL
Zoom in to show the medicine inspection. The zoomed balloon shows the correct suspension.
VOICE-OVER
Next, invert the vial and check the suspension. Confirm the suspension is uniform. If it is not, shake the vial again. It is normal to see some small air bubbles.
TEXT ON SCREEN
Correct suspension should look uniform
VISUAL
The hand positions the vial on the table to allow accumulated bubbles to subside.
VOICE-OVER
In order to accurately administer the exact dose, allow for any excessive bubbles accumulated to subside.
TEXT ON SCREEN
Allow accumulated bubbles to subside.
VISUAL
The hands remove vial cap.
VOICE-OVER
Next, remove the cap from the vial.
VISUAL
The hands clean the rubber stopper.
VOICE-OVER
Clean the rubber stopper with an alcohol wipe and do not allow anything to touch it afterwards.
TEXT ON SCREEN
Do not allow anything to touch the rubber stopper after wiping it.
VISUAL
The hand takes the vial adapter and opens it.
VOICE-OVER
Keeping the vial adapter in the packaging, peel off the paper backing in preparation for the next step.
TEXT ON SCREEN
Keep the adapter in place in the packaging for the next step. The adapter will not fall out when its packaging is turned upside down.
VISUAL
The hand takes the vial adapter and opens it.
VOICE-OVER
With the vial resting in an upright position on a flat surface,
VISUAL
The hand takes the vial adapter and attaches it to the vial.
VOICE-OVER
press the vial adapter straight down onto the vial using the packaging, as shown.
The vial adapter should snap securely into place.
VISUAL
The hand takes the packaging off the vial adapter.
VOICE-OVER
When you are ready, lift off the vial adapter packaging.
VISUAL
The hands take the syringe and withdraw 1 mL of air.
VOICE-OVER
Remove the syringe from the packaging and draw 1 milliliter of air into the syringe.
This will make it easier to draw up the medicine later.
TEXT ON SCREEN
1 mL of air
VISUAL
The hands attach the syringe to vial adapter by screwing the syringe firmly.
VOICE-OVER
With the vial on a flat surface, hold the vial adapter and vial firmly, as shown.
Screw the syringe securely onto the vial adapter.
VISUAL
The hand presses the plunger to push air in the vial.
VOICE-OVER
Press the plunger all the way down to push the air into the vial.
VISUAL
The hands invert syringe and vial together and withdraw all the medicine possible.
VOICE-OVER
Invert the syringe and vial and slowly withdraw as much of the medicine as possible into the syringe.
It is worth noting that there may be more medicine than the dose amount.
TEXT ON SCREEN
Keep the syringe upright to avoid leakage.
VISUAL
The hands unscrew the syringe from vial adapter.
VOICE-OVER
Hold the syringe plunger firmly in place as shown to prevent leakage.
It is normal to feel some back pressure.
Unscrew the syringe from the vial adapter.
TEXT ON SCREEN
Keep the syringe upright to avoid leakage.
Check that the medication looks uniform and milky white.*
*Cabotegravir coloring may vary slightly, ranging from white to light pink.
VISUAL
The hand holds the syringe.
VOICE-OVER
However, the medication can remain in the syringes for up to 2 hours before injecting.
You must discard the filled syringes and needles if this time limit is exceeded. The filled syringes should not be placed in the refrigerator.
TEXT ON SCREEN
The medication can remain in the syringes for up to 2 hours before injecting. The filled syringes should not be placed in the refrigerator.
Discard if this time limit is exceeded.
VISUAL
The hands peel open the needle packaging part way to expose the needle base.
VOICE-OVER
Now, peel open the needle packaging partway to expose
VISUAL
The needle is positioned with its packaging on the table for later.
VOICE-OVER
the needle base.
VISUAL
The hands take the needle with its packaging and attach the needle, firmly twisting the syringe onto the needle.
VOICE-OVER
While keeping the syringe upright, firmly twist the needle onto the syringe,
VISUAL
The needle packaging is removed.
VOICE-OVER
then finally remove the needle from its packaging fully.
VISUAL
A hand holds the label on which has just been written the name of the medicine.
VOICE-OVER
Write the name of the medicine on the syringe label.
It is recommended to also label the syringe with the time that the medication is drawn into the syringe if the medication is not administered immediately.
TEXT ON SCREEN
It is recommended to also label the syringe with the time that the medication is drawn into the syringe if the medication is not administered immediately.
VISUAL
Then the hand applies the label on the syringe.
VOICE-OVER
Affix the label to the syringe, making sure the gradations remain visible.
Preparation is now complete.
VISUAL
The Chapter 2 Injection cover appears
VOICE-OVER
Now you're ready for the injection steps.
TEXT ON SCREEN
CHAPTER 2
Injection
VISUAL
A neutral torso appears. The torso turns while explanations of the correct injection site appear.
VOICE-OVER
The first step is to identify the injection site.
It is important to note that these injections are for gluteal intramuscular use only.
Do not administer intravenously.
There are two possible sites for injection: the ventrogluteal and the upper outer quadrant of the dorsogluteal site.
TEXT ON SCREEN
The first step is to identify the injection site.
Injections of CABENUVA are for gluteal intramuscular use only.
Do not inject intravenously.
VISUAL
The torso turns to show both sides of the body (left and right) while the ventrogluteal site explanation appears.
VOICE-OVER
The ventrogluteal site is recommended.
The administration order is not important.
TEXT ON SCREEN
The ventrogluteal site is recommended.
VISUAL
A pop-up appears to explain the dorsogluteal alternative.
VOICE-OVER
You may also consider the upper outer quadrant of the dorsogluteal injection site, shown here.
Ensure that each injection is administered at separate intramuscular gluteal sites (on opposite sides or at least 2 centimeters apart) during the same visit.
TEXT ON SCREEN
You may also consider the upper outer quadrant of the dorsogluteal injection site.
VISUAL
A pop-up appears to explain the options for the patient position during the injection.
VOICE-OVER
To receive an injection at the ventrogluteal site, the patient can lie in one of two positions.
The first option for the patient is to lie on their side, with the knee bent.
The second option is to lie facedown.
Regardless of the patient's body position, it is important to make sure that the muscle is relaxed prior to injection.
TEXT ON SCREEN
To receive an injection at the ventrogluteal site, the patient can lie in one of two positions:
On their side (with the knee bent)
Lying prone (face down)
Make sure that the muscle is relaxed prior to injection.
VISUAL
We now see the patient lying facedown.
VOICE-OVER
To locate the injection site,
VISUAL
The x-ray view becomes more prominent and call-outs appear to identify landmarks.
VOICE-OVER
place the heel of the hand over the patient's greater trochanter
TEXT ON SCREEN
Greater trochanter of femur
Gluteus medius
Iliac crest
Anterior superior iliac spine
VISUAL
The muscle disappears to let the bones be visible and permit the hand to enter the scene and start the identification of the injection site. The hand is semitransparent to allow the bones to be seen under it.
VOICE-OVER
using the left hand for the patient's right hip or the right hand for the patient's left hip. Position the index finger on or toward the anterior superior iliac spine. Stretch the middle finger away from the index finger, creating a "V" or triangle.
TEXT ON SCREEN
Greater trochanter of femur
Iliac crest
Anterior superior iliac spine
VISUAL
The injection area is now selected and a bull’s-eye appears to mark the site.
VOICE-OVER
The injection site is located within the triangle created by the index finger, the middle finger, and the iliac crest.
TEXT ON SCREEN
Greater trochanter of femur
Iliac crest
Anterior superior iliac spine
VISUAL
We now see the right hand entering the scene with an alcohol swab to clean the injection site.
VOICE-OVER
Clean the injection site with an alcohol wipe. Allow the skin to air dry before continuing. Once the site has been identified and the patient is in the correct position, you can proceed to administer the injection.
TEXT ON SCREEN
Clean the injection site with an alcohol wipe.
Allow the skin to air dry before continuing.
VISUAL
Holding the syringe upright, the left hand takes the needle guard and folds it away from the needle.
VOICE-OVER
Fold the needle guard away from the needle
VISUAL
The needle cap is removed.
VOICE-OVER
and pull off the injection needle cap.
VISUAL
The camera zooms in to show the correct 3-mL dosage.
VOICE-OVER
Hold the syringe with the needle pointing up. Press the plunger to the 3-mL mark to remove extra medicine and any air bubbles, ensuring you have the correct dose prepared.
TEXT ON SCREEN
3 mL
VISUAL
A cross-section pop-up of the skin will appear to show z-track mechanism following the procedure in the scene.
VOICE-OVER
Use the z-track injection technique to minimize medication leakage from the injection site.
TEXT ON SCREEN
Skin
Subcutaneous tissue
Muscle
VISUAL
The left hand stretches the skin about 1 inch to show z-track technique.
VOICE-OVER
Firmly drag the skin covering the injection site, displacing it by about an inch.
Keep it held in this position for the injection.
TEXT ON SCREEN
1 inch (2.5 cm)
Skin
Subcutaneous tissue
Muscle
VISUAL
X-ray vision appears. While the left hand keeps the skin stretched to maintain the z-track, the right hand inserts the needle perpendicularly.
VOICE-OVER
Insert the needle to its full depth, or deep enough to reach the muscle.
TEXT ON SCREEN
Skin
Subcutaneous tissue
Muscle
VISUAL
The thumb slowly presses the plunger down to inject the dose.
VOICE-OVER
Still holding the stretched skin, slowly press the plunger all the way down and ensure that the syringe is empty.
TEXT ON SCREEN
Skin
Subcutaneous tissue
Muscle
Medication
VISUAL
The right hand withdraws the needle and the left one releases the skin immediately. Then the cross-section pop-up will disappear.
VOICE-OVER
Withdraw the needle and release the stretched skin immediately.
TEXT ON SCREEN
Skin
Subcutaneous tissue
Muscle
Medication
VISUAL
We now see the right hand entering the scene with gauze, to apply pressure on the injection site.
VOICE-OVER
Once the needle has been removed, apply pressure to the injection site using gauze.
Do not massage the area. A small adhesive bandage may be used if bleeding occurs.
TEXT ON SCREEN
Do not massage the area.
VISUAL
The right hand, holding the syringe with needle, applies pressure on the table to make the needle guard fold again and make the needle safe.
VOICE-OVER
Fold the needle guard over the needle.
Gently apply pressure using a hard surface to lock the needle guard in place.
VISUAL
The right hand, holding the syringe with needle, applies pressure on the table to make the needle guard fold again and make the needle safe. A click is heard.
VOICE-OVER
The needle guard will make a click when it locks.
TEXT ON SCREEN
click
VISUAL
The right hand enters the scene with syringe and needle to insert them in the sharps disposal container,
VOICE-OVER
Dispose of the used needle, syringe, vial, and adapter
VISUAL
then also disposes the vial with vial adapter.
VOICE-OVER
according to local health and safety laws.
VISUAL
The right hand enters the scene, takes the cabotegravir vial, and exits the scene.
VOICE-OVER
Repeat the preparation and injection steps for the second medicine. It is not important which medicine is injected first or second.
The second medicine must be injected into a separate gluteal intramuscular site (on the opposite side or at least 2 centimeters from the first injection).
TEXT ON SCREEN
Repeat preparation and injection steps for the second medicine.
VISUAL
Closing scene with voice-over that accompanies to the end of the video.
The CABENUVA logo is displayed
VOICE-OVER
Thank you for watching this step-by-step guide for the preparation and injection of CABENUVA.
For more information, and additional safety information, visit CABENUVAhcp.com.
TEXT ON SCREEN
Please see Important Safety Information below and full Prescribing Information, including the instructions for Use, on web page.
VISUAL
References will be displayed.
The CABENUVA logo is displayed.
ViiV Healthcare logo is displayed.
TEXT ON SCREEN
References
- Greenway K. Using the ventrogluteal site for intramuscular injection. Nurs Stand. 1. Greenway K. Using the ventrogluteal site for intramuscular injection. Nurs Stand. 2004;18(25):39-42. doi:10.7748/ns2004.03.18.25.39.c3560
- Kara D, Uzelli D, Karaman D. Using ventrogluteal site in intramuscular injections is a priority or an alternative? Int J Caring Sci. 2015;8(2):507-513.
- Hunt CW. Which site is best for an I.M. injection? Nursing. 2008;38(11):62. doi:10.1097/01.NURSE.0000341089.14071.1e
- Rodger MA, King L. Drawing up and administering intramuscular injections: a review of the literature. J Adv Nurs. 2000;31(3):574-582. doi:10.1046/j.13652648.2000.01312.x
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©2024 ViiV Healthcare or licensor.
PMUS-CBRVID240013 June 2024
Produced in USA.
